Sensorion and Cochlear Announce Collaboration to Study Combination Therapies for Cochlear Implant Patients

  • Sensorion and Cochlear will evaluate SENS-401 in combination with Cochlear’s cochlear implants in preclinical setting in 2018, with potential mid-stage clinical testing to begin as soon as 2019
     
  • Cochlear will invest around €1.6 million and receive an equity stake in Sensorion
     
  • Cochlear will receive a right of first negotiation for SENS-401 global use in combination with certain implantable devices

MONTPELLIER, France and SYDNEY, Australia, Dec. 18, 2017 (GLOBE NEWSWIRE) —  Sensorion (FR0012596468 – ALSEN) a biotech company pioneering novel treatments for inner ear diseases, and Cochlear Limited (ASX:COH), the global leader in implantable hearing solutions, today jointly announce a strategic collaboration focused on improving hearing outcomes in patients with cochlear implants. The collaboration will evaluate therapeutic approaches using SENS-401 in combination with cochlear implants, with preclinical studies initiating in 2018, and potential clinical trials to begin as soon as 2019. As part of this strategic collaboration, Cochlear will invest 1.6 million in shares of Sensorion. In exchange, Cochlear will receive a right of first negotiation for a global license to use SENS-401 in patients with certain implantable devices.  

Cochlear is the global leader in implantable hearing solutions and invests more than AUD$150 million a year in research and development.  The company is also involved in more than 100 research collaborations in 20 countries. Cochlear is the technology and market leader in cochlear implants. These devices replace the function of the damaged inner ear, converting digitally-coded sound into electrical impulses that stimulate the hearing nerve and then the brain, where they are interpreted as sound.

Sensorion, a clinical stage biopharmaceutical company with strong academic and partner networks, scientific excellence and execution capabilities, is focused on delivering first-in-class therapeutics for debilitating inner ear disorders, which represent a global market of more than $10 billion.1 Sensorion is developing SENS-401, a small molecule clinical candidate for hearing loss.

The preclinical combination studies will evaluate SENS-401’s therapeutic effect on hearing outcomes achieved with Cochlear’s implantable devices. SENS-401 has demonstrated in preclinical models (noise and drug induced hearing loss) the capacity to enhance survival and preserve functional integrity of hair cells in the inner ear. It has the potential to improve hearing outcomes for patients undergoing cochlear implant surgery. 

“This innovative approach of combining SENS-401 with cochlear implants may allow for better hearing outcomes,” said Lawrence Lustig, MD, Howard W. Smith Professor and Chair, Department of Otolaryngology-Head & Neck Surgery, Columbia University Medical Center.  “SENS-401 has the potential to provide cochlear protection following the implantation procedure, to support long-term functional stability of the implant, and to prevent continued degeneration in some patients.”

“Addressing hearing loss is a societal priority” said Frank Lin, M.D., Ph.D., Associate Professor of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine. “In particular, it has substantive implications for the cognitive and physical well-being of older adults that will likely have broader effects on public health.”

“Our collaboration has the potential to be transformational for both partners, as well as for patients suffering from hearing loss,” said Nawal Ouzren, CEO of Sensorion. “In children, the sense of hearing is crucial to development, language and learning; in older adults, hearing impairment can be disabling and isolating. We believe that our collaborative efforts could ultimately result in life-changing benefits to implanted  patients and we look forward to initiating mid-stage clinical testing as soon as 2019.”

“Cochlear is committed to advance hearing therapies and we look forward to leveraging our combined knowledge and capabilities,” stated Jan Janssen, Chief Technology Officer of Cochlear. “Sensorion has a promising portfolio of therapeutic candidates and we believe that the demonstrated effects of SENS-401 may strategically complement our technology. We are excited for what our combined efforts could mean for providing even better outcomes for implant recipients.”

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1 Source : Sensorion

About SENS-401 

SENS-401, R-azasetron besylate, is a drug candidate that aims to protect and preserve inner ear tissue when lesions are present that can cause progressive or sequelar hearing impediments. A small molecule that can be taken orally or via an injection, SENS-401 has received Orphan Drug Designation in Europe for the treatment of sudden sensorineural hearing loss, and Orphan Drug Designation from the US FDA for the prevention of Cisplatin-induced ototoxicity in pediatric populations.

About Sensorion
Sensorion is a biotech company pioneering novel treatments for inner ear diseases, such as severe vertigo, tinnitus, or hearing loss. Two products are currently in the clinical development stage: SENS-111, in phase 2 in acute unilateral vestibulopathy (vestibular neuritis), and SENS-401, which has completed a phase 1 trial. The company was founded by Inserm (the French Institute of Health and Medical Research) and is utilizing its pharmaceutical R&D experience and comprehensive technology platform to develop first-in-class, easy-to-administer, notably orally active, drugs for treating and preventing hearing loss and the symptoms of bouts of vertigo and tinnitus. Based in Montpellier, Southern France, Sensorion has received financial support from Bpifrance, through the InnoBio fund, and Inserm Transfert Initiative.
Sensorion has been listed on the Euronext Growth Paris exchange since April 2015.
www.sensorion-pharma.com

About Cochlear Limited
Cochlear is the global leader in implantable hearing solutions. The company has a global workforce of more than 3,000 people and invests more than AUD$150 million a year in research and development. Products include hearing systems for cochlear implants, bone conduction and acoustic implants, which are designed to treat a range of moderate to profound types of hearing loss. More than 450,000 people of all ages, across more than 100 countries, now hear because of Cochlear. 

www.cochlear.com

     
Contacts    
Sensorion 
Nawal Ouzren
CEO

Tél : +33 (0)4 67 20 77 30

  Investor Relations – International
LifeSci Advisors LLC
Chris Maggos, Managing Director,  Europe
chris@lifesciadvisors.com
Tél. : +41 79 367 6254
     
Libellé : SENSORION
Code ISIN : FR0012596468
Mnémonique : ALSEN
  Relations Presse
Alize RP
Caroline Carmagnol & Wendy Rigal
sensorion@alizerp.com
     
Cochlear Limited
Jennifer Stevenson
Head of Corporate Communications 
T: +61 (2) 9611 6959
E: jstevenson@cochlear.com
   
     

Disclaimer 

This press release contains certain forward-looking statements concerning Sensorion and its business. Such forward-looking statements are based on assumptions that Sensorion considers to be reasonable. However, there can be no assurance that such forward-looking statements will be verified, which statements are subject to numerous risks, including the risks set forth in the Document de référence registration document filed with the Autorité des marchés financiers (AMF- French Financial Market Authority) on July 28, 2016 under n°R.16-069 and to the development of economic conditions, financial markets and the markets in which Sensorion operates. The forward-looking statements contained in this press release are also subject to risks not yet known to Sensorion or not currently considered material by Sensorion. The occurrence of all or part of such risks could cause actual results, financial conditions, performance or achievements of Sensorion to be materially different from such forward-looking statements. 

This press release and the information that it contains do not constitute an offer to sell or subscribe for, or a solicitation of an offer to purchase or subscribe for, Sensorion shares in any country. The communication of this press release in certain countries may constitute a violation of local laws and regulations. Any recipient of this press release must inform oneself of any such local restrictions and comply therewith.

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Transparency notification

Mechelen, Belgium; 18 December 2017; 7.30 CET; regulated information – Galapagos NV (Euronext & NASDAQ: GLPG) received a transparency notification from Gilead Sciences, Inc.

Pursuant to Belgian transparency legislation[1], Galapagos received a transparency notification on 13 December 2017 from Gilead Sciences, Inc., who notified that its subsidiary Gilead Biopharmaceutics Ireland UC transferred its holding of 6,760,701 Galapagos shares on 7 December 2017 to its subsidiary Gilead Therapeutics A1 Unlimited Company. This shareholding represents 13.27% of Galapagos’ currently outstanding 50,936,778 shares, and represents no change in the number of shares compared to the previous transparency notification from Gilead Sciences Inc. on 20 January 2016. The full transparency notice is available on the Galapagos website.

About Galapagos
Galapagos (Euronext & NASDAQ: GLPG) is a clinical-stage biotechnology company specialized in the discovery and development of small molecule medicines with novel modes of action. Galapagos’ pipeline comprises Phase 3 through to discovery programs in cystic fibrosis, inflammation, fibrosis, osteoarthritis and other indications. Our target discovery platform has delivered three novel mechanisms showing promising patient results in, respectively, inflammatory diseases, idiopathic fibrosis and atopic dermatitis. Galapagos is focused on the development and commercialization of novel medicines that will improve people’s lives. The Galapagos group, including fee-for-service subsidiary Fidelta, has approximately 578 employees, operating from its Mechelen, Belgium headquarters and facilities in the Netherlands, France, and Croatia. More information at www.glpg.com.

Contact

Investors:

Elizabeth Goodwin
VP IR & Corporate Communications
+1 781 460 1784

Paul van der Horst
Director IR & Business Development
+31 71 750 6707
ir@glpg.com

Media:
Evelyn Fox
Director Communications
+31 6 53 591 999
communications@glpg.com

[1]     Belgian Act of 2 May 2007 on the disclosure of major shareholdings in issuers whose shares are admitted to trading on a regulated market.

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RECORDATI: ACQUIRES TRANSIPEG®, TRANSIPEGLIB® AND COLOPEG® FOR THE FRENCH MARKET

Milan, 18 December 2017 – Recordati announces the purchase of three Bayer Consumer Health brands for the French market: Transipeg®, TransipegLib® and Colopeg®. Transipeg® and TransipegLib® are macrogol based laxatives for the treatment of symptomatic constipation in adults and Colopeg® is a large volume bowel cleanser indicated in preparation for endoscopic exploration. The 2016 net sales of the products in France amount to around € 10 million.

“The acquisition of Transipeg®, TransipegLib® and Colopeg® which are well-known brands in France, is in line with our strategy to reinforce our product portfolio in this market”, declared Andrea Recordati, CEO and Vice Chairman. “We are progressively enhancing our presence in the area of gastroenterology and this line of products provides further product choice for doctors and patients in order to meet their specific needs.”

Recordati, established in 1926, is an international pharmaceutical group, listed on the Italian Stock Exchange (Reuters RECI.MI, Bloomberg REC IM, ISIN IT 0003828271), with a total staff of more than 4,100, dedicated to the research, development, manufacturing and marketing of pharmaceuticals. Headquartered in Milan, Italy, Recordati has operations in the main European countries, in Russia, other Central and Eastern European countries, Turkey, North Africa, the United States of America, Canada, Mexico and in some South American countries.  An efficient field force of medical representatives promotes a wide range of innovative pharmaceuticals, both proprietary and under license, in a number of therapeutic areas including a specialized business dedicated to treatments for rare diseases. Recordati is a partner of choice for new product licenses for its territories. Recordati is committed to the research and development of new specialties with a focus on treatments for rare diseases.  Consolidated revenue for 2016 was € 1,153.9 million, operating income was € 327.4 million and net income was € 237.4 million.

For further information:

Recordati website:  www.recordati.com

Investor Relations                                                                       Media Relations                   
Marianne Tatschke                                                                     Studio Noris Morano                                                           
(39)0248787393                                                                          (39)0276004736, (39)0276004745
e-mail: investorelations@recordati.it                                        e-mail: norismorano@studionorismorano.com
                                                                    

Statements contained in this release, other than historical facts, are “forward-looking statements” (as such term is defined in the Private Securities Litigation Reform Act of 1995). These statements are based on currently available information, on current best estimates, and on assumptions believed to be reasonable. This information, these estimates and assumptions may prove to be incomplete or erroneous, and involve numerous risks and uncertainties, beyond the Company’s control. Hence, actual results may differ materially from those expressed or implied by such forward-looking statements. All mentions and descriptions of Recordati products are intended solely as information on the general nature of the company’s activities and are not intended to indicate the advisability of administering any product in any particular instance.

Attachments:

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